Galaxy clusters provide a unique probe of the late-time cosmic structure and serve as a powerful independent test of the CDM model. This work presents the first set of cosmological constraints derived with ~16,000 optically selected redMaPPer clusters across nearly 5,000 using DES Year 3 data sets. Our analysis leverages a consistent modeling framework for galaxy cluster cosmology and DES-Y3 joint analyses of galaxy clustering and weak lensing (3x2pt), ensuring direct comparability with the DES-Y3 3x2pt analysis. We obtain constraints of and from the cluster-based data vector. We find that cluster constraints and 3x2pt constraints are consistent under the CDM model with a Posterior Predictive Distribution (PPD) value of . The consistency between clusters and 3x2pt provides a stringent test of CDM across different mass and spatial scales. Jointly analyzing clusters with 3x2pt further improves cosmological constraints, yielding and , a improvement in the figure-of-merit over 3x2pt alone. Moreover, we find no significant deviation from the Planck CMB constraints with a probability to exceed (PTE) value of , significantly reducing previous tension claims. Finally, combining DES 3x2pt, DES clusters, and Planck CMB places an upper limit on the sum of neutrino masses of eV at 95% confidence under the CDM model. These results establish optically selected clusters as a key cosmological probe and pave the way for cluster-based analyses in upcoming Stage-IV surveys such as LSST, Euclid, and Roman.

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