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Isospin symmetry, as the most precise flavor symmetry, can be used to extract information about hadronic dynamics. The effective Hamiltonian operators of bottom quark weak decays are zero under a series of isospin lowering operators , which permits us to generate isospin sum rules without the Wigner-Eckart invariants. In this work, we derive hundreds of isospin sum rules for the two- and three-body non-leptonic decays of bottom baryons. They provide hints for new decay modes and the isospin partners of pentaquark states.

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