In this paper, we are concerned with the well-known Brezis-Nirenberg problem \begin{equation*} \begin{cases} -Δu= u^{2^-1}+\varepsilon u^{q-1},\quad u>0, &{~Ω},\ \quad \ \ u=0, &{~\partial Ω}, \end{cases} \end{equation} where with is a bounded domain, and denotes the critical Sobolev exponent. It is well-known (H. Brézis and L. Nirenberg, \newblock {\em Comm. Pure Appl. Math.}, 36(4):437–477, 1983) that the above problem admits a positive least energy solution for all and . In the present paper, we first analyze the asymptotic behavior of the positive least energy solution as and establish a sharp asymptotic characterisation of the profile and blow-up rate of the least energy solution. Then, we prove the uniqueness and nondegeneracy of the least energy solution under some mild assumptions on domain . The main results in this paper can be viewed as a generalization of the results for previously established in the literature. But the situation is quite different from the case , and the blow-up rate not only heavily depends on the space dimension and the geometry of the domain , but also depends on the exponent in a non-trivial way.

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