This study focuses on developing a self-triggered data acquisition system and a noise reduction algorithm for the Multi-gap Resistive Plate Chamber (MRPC) Time-of-Flight Positron Emission Tomography (TOF-PET) system. The system integrates a fast front-end amplifier, a waveform digitization module based on the DRS4 chip, and an efficient noise reduction algorithm to address challenges such as high noise trigger rates and precise gamma-ray detection. The proposed self-triggered system, through threshold discrimination, coincidence logic, and continuous oscillation check, reduces the noise trigger rate to 0.004 Hz. Experimental results show that the system accurately localizes and images the Na radioactive source, and has a good time resolution of 162 ps FWHM for 0.511 MeV gamma rays.

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