We consider the quantum analog of the generalized Zernike systems given by the Hamiltonian: with canonical operators and arbitrary coefficients . This two-dimensional quantum model, besides the conservation of the angular momentum, exhibits higher-order integrals of motion within the enveloping algebra of the Heisenberg algebra in two dimensions. By constructing suitable combinations of these integrals, we uncover a polynomial Higgs-type symmetry algebra that, through an appropriate change of basis, gives rise to a deformed oscillator algebra. The associated structure function is shown to factorize into two commuting components . This framework enables an algebraic determination of the possible energy spectra of the model for the cases , the case being canonically equivalent to the harmonic oscillator. Based on these findings, we propose two conjectures which generalize the results for all and any value of the coefficients . In addition, all of these results can be interpreted as higher-order superintegrable perturbations of the original quantum Zernike system corresponding to , which are also analyzed and applied to the isotropic oscillator on the sphere, hyperbolic and Euclidean spaces

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