We have conducted a planetary radial velocity measurement of the ultra-hot Jupiter WASP-121b using JWST NIRSpec phase curve data. Our analysis reveals the Doppler shift of the planetary spectral lines across the full orbit, which shifts considerably across the detector ( 10 pixels). Using cross-correlation techniques, we have determined an overall planetary velocity amplitude of km/s, which is in good agreement with the expected value. We have also calculated the dynamical mass for both components of the system by treating it as an eclipsing double-line spectroscopic binary, with WASP-121A having a mass of M=1.330 0.019 M, while WASP-121b has a mass of M= 1.170 0.043 M. These dynamical measurements are more precise than previous estimates and do not rely on any stellar modeling assumptions which have a 5% systematic floor mass uncertainty. Additionally, we used stellar evolution modeling constrained with a stellar density and parallax measurement to determine a precise age for the system, found to be 1.11 0.14 Gyr. Finally, we observed potential velocity differences between the two NIRSpec detectors, with NRS1 lower by 5.52.2 km/s. We suggest that differences can arise from day/night asymmetries in the thermal emission, which can lead to a sensitivity bias favoring the illuminated side of the planet, with planetary rotation and winds both acting to lower a measured . The planet’s rotation can account for 1 km/s of the observed velocity difference, with 4.52.2 km/s potentially attributable to vertical differences in wind speeds.

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