In this paper, we consider the existence and multiplicity of prescribed mass solutions to the following nonlinear Schrödinger equation with general nonlinearity: Mass super-critical case: both on large bounded smooth star-shaped domain and on , where is the potential and the nonlinearity considered here are very general and of mass super-critical. The standard approach based on the Pohozaev identity to obtain normalized solutions is invalid as the presence of potential . In addition, our study can be considered as a complement of Bartsch-Qi-Zou (Math Ann 390, 4813–4859, 2024), which has addressed an open problem raised in Bartsch et al. (Commun Partial Differ Equ 46(9):1729–1756, 2021).

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