This work introduces a novel approach to constructing DNA codes from linear codes over a non-chain extension of . We study -constacyclic codes over the ring with an -automorphism and a -derivation over Further, we determine the generators of the -constacyclic codes over the ring of any arbitrary length and establish the reverse constraint for these codes. Besides the necessary and sufficient criterion to derive reverse-complement codes, we present a construction to obtain DNA codes from these reversible codes. Moreover, we use another construction on the -constacyclic codes to generate additional optimal and new classical codes. Finally, we provide several examples of constacyclic codes and construct DNA codes from established results. The parameters of these linear codes over are better and optimal according to the codes available at \cite{z4codes}.

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