In this article, we study -derivations of number rings by considering them as commutative unital -algebras. We begin by characterizing all -derivations and inner -derivations of the ring of algebraic integers of a quadratic number field. Then we characterize all -derivations of the ring of algebraic integers of a -cyclotomic number field ( odd rational prime and a primitive -root of unity). We also conjecture (using SageMath and MATLAB) an \enquote{if and only if} condition for a -derivation on to be inner. We further characterize all -derivations and inner -derivations of the bi-quadratic number ring (, distinct square-free rational integers). In each of the above cases, we also determine the rank and an explicit basis of the derivation algebra consisting of all -derivations of the number ring. As a consequence, we solve the twisted derivation problem in the ring of algebraic integers of a quadratic number field and in a bi-quadratic number ring, and we conjecture a solution of the twisted derivation problem in the ring of algebraic integers of a -cyclotomic number field. Finally, we give the applications of our work in coding theory by constructing Hom-IDD codes.

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