We demonstrate the feasibility of determining the strong coupling constant, , from the inclusive semileptonic decay width of mesons. We express the semileptonic decay width as a function of , the Cabibbo-Kobayashi-Maskawa matrix element , - and -quark masses in the scheme. We fit to current world averages of the and semileptonic decay widths. This yields , corresponding to a 5-flavor extrapolation of . The primary uncertainty contributions arise from the uncertainty on the perturbative expansion and the value of . Future advancements including higher-order perturbative calculations, and precise measurements of and decay widths from upcoming and factories, could enable this method to determine with a competitive precision of . This precision is comparable to the current accuracy of measurements from -lepton decays, which is regarded as the most precise experimental approach.

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