Two families and of sets are called cross-intersecting if each pair of sets and has nonempty intersection. Let and be two cross-intersecting families of -subsets and -subsets of . Matsumoto and Tokushige [J. Combin. Theory Ser. A 52 (1989) 90–97] studied the extremal problem of the size and obtained the uniqueness of extremal families whenever , building on the work of Pyber. This paper will explore the second extremal size of and obtain that if and are not the subfamilies of Matsumoto–Tokushige’s extremal families, then, for or , \begin{itemize} \item[1)]either with the unique extremal families (up to isomorphism) $\mathcal{A=\{A\in {\binom{[n]}{k}}: 1\in A \: \mathrm{ or} \: 2\in A\}$ \quad and \quad $\mathcal{B}=\{B\in {\binom{[n]}{\ell}}: [2] \subseteq B\}$}; \item[2)] or with the unique extremal families (up to isomorphism) $\mathcal{A=\{A\in {\binom{[n]}{k}}: 1\in A\}\cup \{[2,k+1] \}$\quad and \quad $\mathcal{B}=\{B\in {\binom{[n]}{\ell}}: 1\in B, B\cap [2,k+1]\neq \emptyset \}$.} \end{itemize} The bound `` or " is sharp for . To achieve the above results, we establish some size-sensitive inequalities for cross-intersecting families. As by-products, we will recover the main results of Frankl and Kupavskii [European J. Combin. 62 (2017) 263–271].

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