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We consider superconformal gauge theories in four dimensions. We explain how these quiver gauge theories arise as low-energy worldvolume theories of D3-branes on orientifolds. Then, we examine their associated chiral algebras, and propose novel examples of twisted holographic dualities arising in the large-N limit. These dualities involve topological strings in the bulk, which is a Calabi-Yau threefold taking the form .

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