We study the 1/2 BPS circular Wilson loop in four-dimensional SU(N), SYM theories with massless hypermultiplets and non-vanishing -function. Using super-symmetric localization on , we map the path-integral associated with this observable onto an interacting matrix model. Despite the breaking of conformal symmetry at the quantum level, we show that, within a specific regime, the matrix model predictions remain consistent with the perturbative results in flat space up to order . At this order, our analysis reveals that the reorganization of Feynman diagrams based on the matrix model interaction potential, widely tested in (super)conformal models, also applies to these non-conformal set-ups and is realized by interference mechanisms.

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