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We investigate heavy-light quark systems within the framework of the QCD instanton vacuum, focusing on the light flavor case. We derive an effective heavy-light quark interaction from the low-energy QCD partition function and construct a heavy-meson effective Lagrangian. The physical residual mass of heavy mesons, , is determined by employing compositeness and normalization conditions. We calculate the masses of and mesons and their weak decay constants to the leading order and next-to-leading order in the expansion. The current results for and are in good agreement with recent lattice QCD data and PDG average values.

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