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We show that interactions violating the conservation of lepton numbers in the neutrino sector could significantly alter the standard low entropy picture for the pre-supernova collapsing core of a massive star. A rapid neutrino-antineutrino equilibration leads to entropy generation and enhanced electron capture and, hence, a lower electron fraction than in the standard model. This would affect the downstream core evolution, the prospects for a supernova explosion, and the emergent neutrino signal. If realized by lepton-number-violating neutrino self-interactions (LNV SI), the relevant mediator mass and coupling ranges can be probed by future accelerator-based experiments.

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