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We give an algorithm to compute the following cohomology groups on $U = \C^n \setminus V(f)f \in \Q[x_1, …, x_n]H^k(U, \C_U)\C_UU\CH^k(U, \Vsc)\VscU$. We also give partial results on computation of cohomology groups on for a locally constant sheaf of general rank and on computation of $H^k(\C^n \setminus Z, \C)Z$ is a general algebraic set. Our algorithm is based on computations of Gr"obner bases in the ring of differential operators with polynomial coefficients.

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