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In this paper, we study the following biharmonic Schrödinger equation with potential and mixed nonlinearities \begin{equation*} \left{\begin{array}{ll}Δ^2 u +V(x,y)u+λu =μ|u|^{p-2}u+|u|^{q-2}u,\ (x, y) \in Ω_r \times ^n, \ \int_{Ω_r\times^n}u^2dxdy=Θ,\end{array} \right. \end{equation*} where is an open bounded convex domain, is large and . The exponents satisfy , so that the nonlinearity is a combination of a mass subcritical and a mass supercritical term. Under some assumptions on and , we obtain the several existence results on waveguide manifold. Moreover, we also consider the orbital stability of the solution.

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