Let be any unital commutative -algebra and commutative or noncommutative free variables. Let be a formal parameter which commutes with and elements of . We denote uniformly by and the formal power series algebras of over and , respectively. For any , let be the unital algebra generated by the differential operators of which increase the degree in by at least and the group of automorphisms of with and . First, for any fixed and , we introduce five sequences of differential operators of and show that their generating functions form a CS (noncommutative symmetric) system [Z4] over the differential algebra . Consequently, by the universal property of the CS system formed by the generating functions of certain NCSFs (noncommutative symmetric functions) first introduced in [GKLLRT], we obtain a family of Hopf algebra homomorphisms , which are also grading-preserving when satisfies certain conditions. Note that, the homomorphisms above can also be viewed as specializations of NCSFs by the differential operators of . Secondly, we show that, in both commutative and noncommutative cases, this family (with all and ) of differential operator specializations can distinguish any two different NCSFs. Some connections of the results above with the quasi-symmetric functions ([Ge], [MR], [S]) are also discussed.

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