A topological index theorem for manifolds with corners

We define an analytic index and prove a topological index theorem for a non-compact manifold $M\mathrm{\_}0$ with poly-cylindrical ends. We prove that an elliptic operator $P$ on $M\mathrm{\_}0$ has an invertible perturbation $P+R$ by a lower order operator if an only if its analytic index vanishes. As an application, we determine the $K$-theory groups of groupoid $C^{\ast }$–algebras of manifolds with corners.