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We establish the Thom isomorphism in twisted K-theory for any real vector bundle and develop the push-forward map in twisted K-theory for any differentiable proper map (not necessarily K-oriented). The push-forward map generalizes the push-forward map in ordinary K-theory for any -oriented differentiable proper map and the Atiyah-Singer index theorem of Dirac operators on Clifford modules. For -branes satisfying Freed-Witten’s anomaly cancellation condition in a manifold with a non-trivial -field, we associate a canonical element in the twisted K-group to get the so-called D-brane charges.

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