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We prove local and global well-posedness for semi-relativistic, nonlinear Schr"odinger equations with initial data in , . Here is a critical Hartree nonlinearity that corresponds to Coulomb or Yukawa type self-interactions. For focusing , which arise in the quantum theory of boson stars, we derive a sufficient condition for global-in-time existence in terms of a solitary wave ground state. Our proof of well-posedness does not rely on Strichartz type estimates, and it enables us to add external potentials of a general class.

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