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Let E be an elliptic curve defined over a number field F, and let p be a prime >= 5. In this paper we study the structure of the Selmer group of E over p-adic Lie extensions of F. In particular, under certain global and local conditions on we relate the generalised $Gal(F_\infty / F)Sel(E / F_\infty)$ to the generalised Euler characteristic of the Selmer group over the cyclotomic Zp-extension of F. This invariant generalises the classical Euler characteristic to the case when the rank of E(F) is positive. Moreover, we show that the global and local conditions on are satisfied for a large class of p-adic Lie extensions of F .

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