In a previous paper, the authors showed that the category of E(n)*E(n)-comodules is a localization of the category of BPBP-comodules. In this paper, we study the resulting localization functor L_n on the category of BP_BP-comodules. It is an algebraic analogue of the usual topological localization L_n. It is left exact, so has right derived functors L_n^i. We show that these derived functors are closely related to the local cohomology groups of BP_-modules studied by Greenlees and May; in fact, they coincide with Cech cohomology with respect to I_{n+1}. We also construct a spectral sequence of comodules analogous to the Greenlees-May spectral sequence (of modules) converging to BP_(L_n X) whose E_2-term involves L_n^i(BP_*X). The proofs require getting a partial understanding of injective objects in the category of BP_*BP-comodules.

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