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We introduce in this paper the notion of noncommutative Serre fibration (shortly, NCSF) and show that up to homotopy, every NCCW complex morphism is some noncommutative Serre fibration. We then deduce a six-term exact sequence for the periodic cyclic homology and for K-theory of an arbitrary noncommutative Serre fibration. We also show how to use this technique to compute K-theory and cyclic theory of some noncommutative quotients.

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