We establish the global-in-time well-posedness of the two-dimensional incompressible Navier-Stokes equations with freely transported viscosity coefficient, under a scaling-invariant smallness condition on the initial data. The viscosity coefficient is allowed to exhibit large jumps across -interfaces. The viscous stress tensor is carefully analyzed. Specifically, , where denotes the Riesz operator, defines a good unknown'' that satisfies time-weighted $H^1$-energy estimates. Combined with tangential regularity, this leads to the $W^{1,2+ε}$-regularity of another good unknown’', , where and denote the unit tangential and normal vectors of the interfaces, respectively. These results collectively provide a Lipschitz estimate for the velocity field, even in the presence of significant discontinuities in . As applications, we investigate the well-posedness of the Boussinesq equations without heat conduction and the density-dependent incompressible Navier-Stokes equations in two spatial dimensions.

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