After discussing the peculiarities of quantum systems on noncommutative (NC) spaces with non-trivial topology and the operator representation of the -product on them, we consider the Aharonov-Bohm and Casimir effects for such spaces. For the case of the Aharonov-Bohm effect, we have obtained an explicit expression for the shift of the phase, which is gauge invariant in the NC sense. The Casimir energy of a field theory on a NC cylinder is divergent, while it becomes finite on a torus, when the dimensionless parameter of noncommutativity is a rational number. The latter corresponds to a well-defined physical picture. Certain distinctions from other treatments based on a different way of taking the noncommutativity into account are also discussed.

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