We generalize the spectral-curve construction of moduli spaces of instantons on and to noncommutative geometry. We argue that the spectral-curves should be constructed inside a twisted or that is an elliptic fibration without a section. We demonstrate this explicitly for and to first order in the noncommutativity, for . Physically, moduli spaces of noncommutative instantons appear as moduli spaces of theories with supersymmetry in 2+1D. The spectral curves are related to Seiberg-Witten curves of theories with in 3+1D. In particular, we argue that the moduli space of instantons of Yang-Mills theories on a noncommutative is equivalent to the Coulomb branch of certain 2+1D theories with supersymmetry. The theories are obtained by compactifying the heterotic little-string theory on with global twists. This extends a previous result for noncommutative instantons on . We also briefly discuss the instanton equation on generic curved spaces.

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