A general theoretical framework that incorporates possible CPT and Lorentz violation in an extension of the standard model and in quantum electrodynamics has been developed over the last decade. The framework originates in the idea that CPT and Lorentz symmetry could be broken spontaneously in a more fundamental theory such as string theory. These symmetry violations are described in the standard-model extension by small terms in the Lagrangian. Various experiments can bound these quantities. They include Penning-trap experiments with electrons and positrons, Penning-trap experiments with protons and antiprotons, and possible experiments with hydrogen and antihydrogen in traps or beams. I will review aspects of the theory, outline estimated bounds attainable in specific experiments, and present known bounds from completed experiments.

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