Define the nuclear dependence coefficient in terms of ratio of transverse momentum spectrum in hadron-nucleus and in hadron-nucleon collisions: $\frac{d\sigma^{hA}}{dq_T^2}/ \frac{d\sigma^{hN}}{dq_T^2}\equiv A^{\alpha(A,q_T)}q_T\alpha(A,q_T)\psiproduction is given by a universal function:\a+b q_T^2$, where parameters a and b are completely determined by either calculable quantities or independently measurable physical observables. We demonstrate that this universal function is insensitive to the A for normal nuclear targets. For a color deconfined nuclear medium, the becomes strongly dependent on the A. We also show that our for the Drell-Yan process is naturally linked to perturbatively calculated at large without any free parameters, and the is consistent with E772 data for all .

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