We utilize asymptotic Pade-approximant methods to estimate the three-loop order MS bar-scheme coefficients within the inclusive semileptonic b to u decay rate for four and five active quark flavours. The estimates we obtain for the three renormalization-group-accessible coefficients within the three-loop contribution are all found to be within 5.1% of their true values, using a least-squares procedure in conjunction with an asymptotic Pade-approximant estimate of the three-loop term over the entire domain. Given the input values and $m_b(m_b) =4.17 \pm 0.05 GeV$, the three-loop expression for the purely-perturbative contribution to the decay rate is minimally sensitive to renormalization scale at $\mu = 1.775 GeV$, at which scale the three-loop contribution is estimated to be only 1.4% of the leading tree-order contribution. We estimate the full perturbative decay rate to be $192\pi^3\Gamma(b\to u\bar\nu_\ell\ell^-)/(G_F^2| V_{ub}|^2) = 2070 {\rm GeV^5} \pm 16%$, inclusive of theoretical uncertainties from series truncation, the input parameters, and the estimation procedure.

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