We study charged Higgs boson production at future electron-proton colliders in the framework of the Minimal Supersymmetric Standard Model. We focus our attention to the case of single-top production and decay through the channel and of vector-scalar fusion via (where and ). We consider the signature and compare it to the irreducible background from Standard Model interactions. For , the signal is accessible through lepton universality breaking if GeV at both low and large values of . Furthermore, although the bulk of the production cross section comes from single-top events, a sizable contribution due to vector-scalar-scalar interactions should be observable at large , this possibly offering some insights into the structure of the scalar sector of the theory. The possibility of the CERN collider running in the LEPXLHC mode is considered in detail

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