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We study an interacting ensemble of instantons at finite baryon chemical potential. We emphasize the importance of fermionic zero modes and calculate the fermion induced interaction between instantons at non-zero chemical potential. We show that unquenched simulations of the instanton ensemble are feasible in two regimes, for sufficiently small and for very large chemical potential. At very large chemical potential chiral symmetry is restored and the instanton ensemble is dominated by strongly correlated chain-like configurations.

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