We compute the perturbative QCD contribution to semileptonic B decay, including the finite mass of the charm quark. This result provides an estimate of the size of the two-loop correction, which is found to be about 50% of the one-loop correction. We use these results to set the scale for the one-loop correction using the scheme of Brodsky, Lepage and Mackenzie and find a BLM scale of , when the inclusive semileptonic rate is expressed in terms of the and quark pole masses and the \msbar strong coupling. The two loop correction lies roughly midway between that obtained at and that obtained in the Shifman-Voloshin limit $m_b, m_c\gg m_b-m_c\gg\Lambda_{\rm QCD}$ while the corresponding BLM scale is somewhat closer to that obtained in the former case.

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