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We introduce a method for the study of CP-violating asymmetries in tagged states of neutral mesons with arbitrary coherence properties. A set of time-dependent measurements is identified which completely specifies the density matrix of the initial state in a two-component space with basis vectors and , and permits a determination of phases in the Cabibbo-Kobayashi-Maskawa matrix. For a given tagging configuration, the measurement of decays both to flavor eigenstates and to CP eigenstates provides the necessary information.

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