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We calculate the new physics contributions to the rare semileptonic decay $B \to X_s l^+ l^-$ induced by the charged-Higgs loop diagrams appeared in the top quark two-Higgs doublet model (T2HDM). Within the considered parameter space, we found that (a) the effective Wilson coefficients ( and ) in the T2HDM are always standard model like; (b) the new physics contributions to and can be significant, but they tend to cancel each other; and © the T2HDM predictions for agree well with the measured value within one standard deviation.

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