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The production of charmonia in relativistic heavy-ion collisions is formulated within the framework of a quantum kinetic theory simultaneously accounting for breakup and recombination processes. The survival probability of J/Psi mesons is evaluated for a Mott-Hagedorn resonance gas, whereby the pattern of anomalous J/Psi suppression at CERN-SPS can be explained by a strong coupling to open-charm states and their in-medium modification. Recent data for charmonium suppression from Au-Au collisions at RHIC are discussed.

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