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We implement inflation within a realistic supersymmetric SO(10) model in which the doublet-triplet splitting is realized through the Dimopoulos-Wilczek mechanism, the MSSM problem is resolved, and higgsino mediated dimension five nucleon decay is heavily suppressed. The cosmologically unwanted topological defects are inflated away, and from , the breaking scale is estimated to be of order GeV. Including supergravity corrections, the scalar spectral index , with .

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