We consider five dimensional (5D) supersymmetric SO(10) compactified on the orbifold such that the SO(10) gauge symmetry is broken on both fixed points (branes), and the residual gauge symmetry is . We explore one example in which the gauge symmetries on the two branes are respectively $SU(5)\times U(1)_XSU(4)_c\times SU(2)_L\times SU(2)_R$, and the MSSM gauge symmetry is recovered by the usual Higgs mechanism. We discuss how fermion masses and mixings can be understood in this framework by introducing a flavor symmetry. Unification of the MSSM gauge couplings and proton stability are also considered. An order of magnitude increase in sensitivity could reveal proton decay.

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