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We have calculated the Wilson coefficients (i=1,2) in the renormalization scheme in the model III 2HDM. Using the obtained Wilson coefficients, we have analyzed the CP violation in decays $B^0_q\to l^+l^-A_{CP}$, depends on the parameters of models and in can be as large as 40% and 35% for and respectively. It can reach 4% for decays. Because in SM CP violation is smaller than or equal to O() which is unobservably small, an observation of CP asymmetry in the decays $B^0_q \to l^+l^- (q=d,s)$ would unambiguously signal the existence of new physics.

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