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It is shown how the QCD sum rules can be applied for the investigation of the density dependence of the nucleon parameters. These characteristics can be expressed through the expectation values of QCD operators in nuclear matter. In certain approximations the expectation values are related to the observables. First applications of the approach reproduced some of the basic features of nuclear physics, providing also a new knowledge. The program of the future work is presented. The difficulties of the approach are discussed.

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