We study the effects of non-commutative QED (NCQED) in fermion pair
production, gamma + gamma to f + \bar{f} and Compton scattering, e + gamma to e
- gamma. Non-commutative geometries give rise to 3- and 4-point photon vertices
and to momentum dependent phase factors in QED vertices which will have
observable effects in high energy collisions. We consider e^+ e^- colliders
with energies appropriate to the TeV Linear Collider proposals and the
multi-TeV CLIC project operating in gamma gamma and e gamma modes.
Non-commutative scales roughly equal to the center of mass energy of the e^+e^-
collider can be probed, with the exact value depending on the model parameters
and experimental factors. The Compton process is sensitive to Lambda_{NC}
values roughly twice as large as those accessible to the pair production
process.