We discuss a five dimensional inflationary scenario based on a supersymmetric SO(10) model compactified on . Inflation is implemented through scalar potentials on four dimensional branes, and a brane-localized Einstein-Hilbert term is essential to make both brane vacuum energies positive during inflation. The orbifold boundary conditions break the SO(10) gauge symmetry to (). The inflationary scenario yields , which fixes , the symmetry breaking scale of to be close to the SUSY GUT scale of GeV. The scalar spectral index is , while the gravitational wave contribution to the quadrupole anisotropy is negligible (\lapproxeq 1 {%}). The inflaton decay into the lightest right handed neutrinos yields the observed baryon asymmetry via leptogenesis.

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