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We report on the status of the calculation of deep-inelastic structure functions at three loops in perturbative QCD. The method employed allows to calculate the Mellin moments of structure functions analytically as a general function of N. As an illustration, we present the leading fermionic contributions to the non-singlet anomalous dimension of F_2 at three loops and, as a new result, to the non-singlet coefficient function of F_2 at three loops.

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