We study the flavor physics in two extensions of the quark sector of the Standard Model (SM): a four generation model and a model with a single vector–like down–type quark (VDQ). In our analysis we take into account the experimental constraints from tree–level charged current processes, rare Kaon decay processes, rare B decay processes, the decay, , and mass differences, and the CP violating parameters $\frac \epsilon^\prime}{\epsilon}\epsilon_Ka_{\psi K}$. All the constraints are taken at two sigma. We find bounds on parameters which can be used to represent the New Physics contributions in these models ($\lambda_{t^ \prime}^{bd}\lambda_{t^ \prime}^{bs}\lambda_{t^ \prime}^{sd}$ in the four–generation model, and , and in the VDQ model) due to all the above constraints. In both models the predicted ranges for (the CP asymmetry in semi-leptonic decays), , , and $B(K_L\to \mu \bar{\mu})_{SD}$ can be significantly higher than the predictions of the SM, while the allowed ranges for and for are consistent with the SM prediction.

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