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We discuss properties of QCD with variable and large , taking into account electroweak interactions; i.e., we analyze the generalization of the standard model based on the gauge group $G={\rm SU}(N_c) \times {\rm SU(2)}_L \times {\rm U(1)}_Y$. General classes of solutions to anomaly constraints are given, and it is shown that these allow a quark or lepton rather than the neutrino as an electrically neutral fermion. The issue of grand unification is addressed, and it is shown that cannot be embedded in the usual way in a simple SO() or SU() gauge group unless . The ratio of strengths of QCD and electroweak interactions is discussed.

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