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We study a supersymmetric E6 grand unified model in which the SU(5) 5^* components are twisted in the third generation 27. Supplementing the adjoint Higgs field to a model analyzed previously, we calculate the mass matrices for the up and down quarks and charged leptons. Although the number of free parameters is less than that of observables, an overall fitting to the observed masses and mixing angles is shown to be possible. Most notably, we find two novel, parameter-independent relations between the lepton 2-3 mixing angle and the quark masses and CKM mixing angles that are in good agreement with the large lepton mixing recently observed.

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