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Standard lattice fermion algorithms run into the well-known sign problem at real chemical potential. In this paper we investigate the possibility of using imaginary chemical potential, and argue that it has advantages over other methods, particularly for probing the physics at finite temperature as well as density. As a feasibility study, we present numerical results for the partition function of the two-dimensional Hubbard model with imaginary chemical potential. We also note that systems with a net imbalance of isospin may be simulated using a real chemical potential that couples to I_3 without suffering from the sign problem.

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