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The large-angular-scale anisotropy of the cosmic microwave background radiation in multidimensional cosmological models (Kaluza-Klein models) is studied. Limits on parameters of the models imposed by the experimental data are obtained. It is shown that in principle there is a room for Kaluza-Klein models as possible candidates for the description of the Early Universe. However, the obtained limits are very restrictive and none of the concrete models, analyzed in the article, satisfy them.

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