We describe the time evolution of quantum systems in a classical background space-time by means of a covariant derivative in an infinite dimensional vector bundle. The corresponding parallel transport operator along a timelike curve is interpreted as the time evolution operator of an observer moving along . The holonomy group of the connection, which can be interpreted as a group of local symmetry transformations, and the set of observables have to satisfy certain consistency conditions. Two examples related to local and -symmetries, respectively, are discussed in detail. The theory developed in this paper may also be useful to analyze situations where the underlying space-time manifold has closed timelike curves.

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