What Casimir Energy can suggest about Space Time Foam?

In the context of a model of space-time foam, made by $N$ wormholes we discuss the possibility of having a foam formed by different configurations. An equivalence between Schwarzschild and Schwarzschild-Anti-de Sitter wormholes in terms of Casimir energy is shown. An argument to discriminate which configuration could represent a foamy vacuum coming from Schwarzschild black hole transition frequencies is used. The case of a positive cosmological constant is also discussed. Finally, a discussion involving charged wormholes leads to the conclusion that they cannot be used to represent a ground state of the foamy type.